Dataset Information
Daily Walking and the Risk of Knee Replacement Over 5 Years Among Adults With Advanced Knee Osteoarthritis in the United States.
Ontology highlight
ABSTRACT: Objective
To examine the association of the volume and intensity of daily walking at baseline with the risk of knee replacement (KR) over 5 years in adults with advanced structural knee osteoarthritis.Design
Prospective, longitudinal, and multicenter observational study.Setting
Osteoarthritis Initiative study with follow-up from 2008-2015.Participants
Community-dwelling adults with or at risk of knee osteoarthritis were recruited from 4 sites in the United States (N=516; mean age, 67.7±8.6y; body mass index, 29.3±4.7 kg/m2; 52% female). We included participants with advanced structural disease, without KR and had valid daily walking data (quantified using Actigraph GT1M), at baseline.Interventions
Not applicable.Main outcomes
KR. Walking volume was measured as steps/day and intensity as minutes/day spent not walking (0 steps/min) and walking at very light (1-49 steps/min), light (50-100 steps/min), or moderate (>100 steps/min) intensities. To examine the relationship of walking volume and intensity with the risk of KR, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for covariates.Results
Of 516 adults with advanced structural disease, 88 received a KR over 5 years (17%). Walking an additional 1000 steps/d was not associated with the risk of KR (adjusted HR=0.95; 95% CI, 0.84-1.04). Statistically, replacing 10 min/d of very light and light walking with 10 min/d of moderate walking reduced the risk of KR incidence by 35% and 37%, respectively (adjusted HR=0.65, 95% CI, 0.45-0.94, for very light and adjusted HR=0.63; 95% CI, 0.40-1.00, for light).Conclusions
Daily walking volume and intensity did not increase KR risk over 5 years and may be protective in some cases in adults with advanced structural knee osteoarthritis.
SUBMITTER: Master H
PROVIDER: S-EPMC8487939 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Daily Walking and the Risk of Knee Replacement Over 5 Years Among Adults With Advanced Knee Osteoarthritis in the United States.
Archives of physical medicine and rehabilitation 20210624 10
<h4>Objective</h4>To examine the association of the volume and intensity of daily walking at baseline with the risk of knee replacement (KR) over 5 years in adults with advanced structural knee osteoarthritis.<h4>Design</h4>Prospective, longitudinal, and multicenter observational study.<h4>Setting</h4>Osteoarthritis Initiative study with follow-up from 2008-2015.<h4>Participants</h4>Community-dwelling adults with or at risk of knee osteoarthritis were recruited from 4 sites in the United States ...[more]