Functional connectivity within an anxiety network and associations with anxiety symptom severity in middle-aged adults with and without autism.

ABSTRACT: Anxiety is highly prevalent in autism spectrum disorders (ASDs). However, few functional magnetic resonance imaging (fMRI) studies of ASDs have focused on anxiety (and fewer still on anxiety in middle-aged adults). Thus, relationships between atypical connectivity and anxiety in this population are poorly understood. The current study contrasted functional connectivity within anxiety network regions across adults (40-64 years) with and without autism, and tested for group by functional connectivity interactions on anxiety. Twenty-two adults with ASDs (16 males) and 26 typical control (TC) adults (22 males) completed the Beck Anxiety Inventory and a resting-state fMRI scan. An anxiety network consisting of 12 regions of interest was defined, based on a meta-analysis in TC individuals and tw

SUBMITTER: Tung R 

PROVIDER: S-EPMC8487970 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature