Neuroblastoma Formation Requires Unconventional CD4 T Cells and Arginase-1-Dependent Myeloid Cells.

ABSTRACT: Immune cells regulate tumor growth by mirroring their function as tissue repair organizers in normal tissues. To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunologic manipulation with noninvasive, longitudinal imaging, we generated a penetrant double oncogene-driven autochthonous model of neuroblastoma. Spatial transcriptomic analysis showed that CD4⁺ and myeloid populations colocalized within the tumor parenchyma, while CD8⁺ T cells and B cells were peripherally dispersed. Depletion of CD4⁺ T cells or CCR2⁺ macrophages, but not B cells, CD8⁺ T cells, or natural killer (NK) cells, prevented tumor formation. Tumor CD4⁺ T cells displayed unconventional phenoty

SUBMITTER: Van de Velde LA 

PROVIDER: S-EPMC8488023 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature