Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation.
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ABSTRACT:
SUBMITTER: Kabiri Y
PROVIDER: S-EPMC8488156 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Mitochondrial Impairment by MitoBloCK-6 Inhibits Liver Cancer Cell Proliferation.
Kabiri Yaschar Y Fuhrmann Anna A Becker Anna A Jedermann Luisa L Eberhagen Carola C König Ann-Christine AC Silva Tiago Barros TB Borges Fernanda F Hauck Stefanie M SM Michalke Bernhard B Knolle Percy P Zischka Hans H
Frontiers in cell and developmental biology 20210920
Augmenter of liver regeneration (ALR) is a critical multi-isoform protein with its longer isoform, located in the mitochondrial intermembrane space, being part of the mitochondrial disulfide relay system (DRS). Upregulation of <i>ALR</i> was observed in multiple forms of cancer, among them hepatocellular carcinoma (HCC). To shed light into ALR function in HCC, we used MitoBloCK-6 to pharmacologically inhibit ALR, resulting in profound mitochondrial impairment and cancer cell proliferation defici ...[more]
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