Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities.

ABSTRACT: Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their endogenous characteristics, however, further bioengineering refinement is required to address clinical and commercial limitations. Clinical applications of EV-based therapeutics are being trialed in immunomodulation, tissue regeneration and recovery, and as delivery vectors for combination therapies. Native/biological EVs possess diverse endogenous properties that offer stability and facilitate crossing of biological barriers for delivery of molecular cargo to cells, acting as a form of intercellular communication to regulate function and phenotype. Moreover, EVs are important components of paracrine signaling in stem/progenitor cell-based therapies, are employed as standalone therapies, and can be used

SUBMITTER: Claridge B 

PROVIDER: S-EPMC8488228 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature