Parental preconception exposure to phenol and phthalate mixtures and the risk of preterm birth.

ABSTRACT:

Background

Parental preconception exposure to select phenols and phthalates was previously associated with increased risk of preterm birth in single chemical analyses. However, the joint effect of phenol and phthalate mixtures on preterm birth is unknown.

Methods

We included 384 female and 211 male (203 couples) participants seeking infertility treatment in the Environment and Reproductive Health (EARTH) Study who gave birth to 384 singleton infants between 2005 and 2018. Mean preconception urinary concentrations of bisphenol A (BPA), parabens, and eleven phthalate biomarkers, including di(2-ethylhexyl) phthalate (DEHP) metabolites, were examined. We used principal component analysis (PCA) with log-Poisson regression and Probit Bayesian Kernel Machine Regression (BKMR) with

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8488320 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature