Computational study and in vitro alpha-glucosidase inhibitory effects of medicinal plants from a Thai folk remedy.

ABSTRACT: The number of patients with type 2 diabetes mellitus (T2DM) has increased worldwide. Although an instant cure was achieved with the standard treatment acabose, unsatisfactory symptoms associated with cardiovascular disease after acabose administration have been reported. Therefore, it is important to explore new treatments. A Thai folk recipe has long been used for T2DM treatment, and it effectively decreases blood glucose. However, the mechanism of this recipe has never been proven. Therefore, the potential anti-T2DM effect of this recipe, which is used in Thai hospitals, was determined to involve alpha-glucosidase (AG) inhibition with a half maximal inhibitory concentration (IC₅₀). In vitro experiments showed that crude Cinnamomum verum extract (IC₅₀ =

SUBMITTER: Eawsakul K 

PROVIDER: S-EPMC8488491 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature