A Randomized Controlled Trial of Comparative Efficacy between Sodium Bicarbonate and Heparin as A Locking Solution for Tunneled Central Venous Catheters Among Patients Requiring Maintenance Hemodialysis.

ABSTRACT:

Background

Sodium bicarbonate (NaHCO₃) is one of the promising solutions that has good safety profile and theoretical advantages regarding antimicrobial and antithrombotic properties but there are still limited reports.

Objective

To compare the efficacy in lowering rate of catheter loss due to catheter-related thrombosis (CRT) or catheter-related blood stream infection (CRBSI) between sodium bicarbonate and heparin lock in prevalent chronic hemodialysis (HD) patients.

Design

A multicenter, randomized, open-label study.

Setting

In a developing country, Thailand.

Patients

Chronic HD patients with tunneled central venous catheter.

Measurements

Catheter loss rate, rate of catheter-related blood stream infection, catheter-related thrombosis,

SUBMITTER: Wathanavasin W 

PROVIDER: S-EPMC8488503 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature