Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.

ABSTRACT:

Objectives

Abnormal expression of metabolic rate-limiting enzymes drives the occurrence and progression of hepatocellular carcinoma (HCC). This study aimed to elucidate the comprehensive model of metabolic rate-limiting enzymes associated with the prognosis of HCC.

Materials and methods

HCC animal model and TCGA project were used to screen out differentially expressed metabolic rate-limiting enzyme. Cox regression, least absolute shrinkage and selection operation (LASSO) and experimentally verification were performed to identify metabolic rate-limiting enzyme signature. The area under the receiver operating characteristic curve (AUC) and prognostic nomogram were used to assess the efficacy of the signature in the three HCC cohorts (TCGA training cohort, internal cohort and a

SUBMITTER: Wang Z 

PROVIDER: S-EPMC8488553 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature