Sex and race contribute to variation in mitochondrial function and insulin sensitivity.

ABSTRACT:

Objective

Insulin sensitivity is lower in African American (AA) versus Caucasian American (CA). We tested the hypothesis that lower insulin sensitivity in AA could be explained by mitochondrial respiratory rates, coupling efficiency, myofiber composition, or H₂ O₂ emission. A secondary aim was to determine whether sex affected the results.

Methods

AA and CA men and women, 19-45 years, BMI 17-43 kg m² , were assessed for insulin sensitivity (SI_Clamp ) using a euglycemic clamp at 120 mU/m² /min, muscle mitochondrial function using high-resolution respirometry, H₂ O₂ emission using amplex red, and % myofiber composition.

Results

SI_Clamp was greater in CA (p < 0.01) and women (p < 0.01

SUBMITTER: Fisher G 

PROVIDER: S-EPMC8488557 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature