Ontology highlight
ABSTRACT:
SUBMITTER: Vijayakumar S
PROVIDER: S-EPMC8488602 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Vijayakumar Supreeta S Angione Claudio C
STAR protocols 20210929 4
Combining a computational framework for flux balance analysis with machine learning improves the accuracy of predicting metabolic activity across conditions, while enabling mechanistic interpretation. This protocol presents a guide to condition-specific metabolic modeling that integrates regularized flux balance analysis with machine learning approaches to extract key features from transcriptomic and fluxomic data. We demonstrate the protocol as applied to <i>Synechococcus</i> sp. PCC 7002; we a ...[more]