An organic transistor matrix for multipoint intracellular action potential recording.

ABSTRACT: Electrode arrays are widely used for multipoint recording of electrophysiological activities, and organic electronics have been utilized to achieve both high performance and biocompatibility. However, extracellular electrode arrays record the field potential instead of the membrane potential itself, resulting in the loss of information and signal amplitude. Although much effort has been dedicated to developing intracellular access methods, their three-dimensional structures and advanced protocols prohibited implementation with organic electronics. Here, we show an organic electrochemical transistor (OECT) matrix for the intracellular action potential recording. The driving voltage of sensor matrix simultaneously causes electroporation so that intracellular action potentials are recorded wi

SUBMITTER: Jimbo Y 

PROVIDER: S-EPMC8488610 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature