Crystal structures of human coronavirus NL63 main protease at different pH values.

ABSTRACT: Human coronavirus NL63 (HCoV-NL63), which belongs to the genus Alphacoronavirus, mainly infects children and the immunocompromized and is responsible for a series of clinical manifestations, including cough, fever, rhinorrhoea, bronchiolitis and croup. HCoV-NL63, which was first isolated from a seven-month-old child in 2004, has led to infections worldwide and accounts for 10% of all respiratory illnesses caused by etiological agents. However, effective antivirals against HCoV-NL63 infection are currently unavailable. The HCoV-NL63 main protease (M^pro), also called 3C-like protease (3CL^pro), plays a vital role in mediating viral replication and transcription by catalyzing the cleavage of replicase polyproteins (pp1a and pp1ab) into functional subunits. Moreover, M

SUBMITTER: Gao H 

PROVIDER: S-EPMC8488857 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature