Higher fasting plasma FGF21 concentration is associated with lower ad libitum soda consumption in humans.

ABSTRACT:

Background

The hepatokine fibroblast growth factor 21 (FGF21) influences eating behavior and sugar consumption in rodent models. However, whether circulating FGF21 concentration is associated with food and soda intake in humans is still unclear.

Objective

We investigated whether fasting plasma FGF21 concentration is associated with objective measures of ad libitum food intake and soda consumption.

Methods

Healthy individuals [n = 109; 69 men, aged 34 ± 10 y; BMI (kg/m2): 30.4 ± 7.7; body fat by DXA: 30.5% ± 8.9%] with available plasma for hormonal measurements participated in an inpatient cohort study to objectively quantify ad libitum food and soda intake for 3 d using an automated and reproducible vending machine paradigm. Fasting plasma FGF21 concentration was meas

SUBMITTER: Basolo A 

PROVIDER: S-EPMC8488863 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature