Intrinsic positional memory guides target-specific axon regeneration in the zebrafish vagus nerve.

ABSTRACT: Regeneration after peripheral nerve damage requires that axons re-grow to the correct target tissues in a process called target-specific regeneration. Although much is known about the mechanisms that promote axon re-growth, re-growing axons often fail to reach the correct targets, resulting in impaired nerve function. We know very little about how axons achieve target-specific regeneration, particularly in branched nerves that require distinct targeting decisions at branch points. The zebrafish vagus motor nerve is a branched nerve with a well-defined topographic organization. Here, we track regeneration of individual vagus axons after whole-nerve laser severing and find a robust capacity for target-specific, functional re-growth. We then develop a new single-cell chimera injury model for

SUBMITTER: Isabella AJ 

PROVIDER: S-EPMC8489019 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature