Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish.

ABSTRACT:

Background

Zebrafish pigment cell differentiation provides an attractive model for studying cell fate progression as a neural crest progenitor engenders diverse cell types, including two morphologically distinct pigment cells: black melanophores and reflective iridophores. Nontrivial classical genetic and transcriptomic approaches have revealed essential molecular mechanisms and gene regulatory circuits that drive neural crest-derived cell fate decisions. However, how the epigenetic landscape contributes to pigment cell differentiation, especially in the context of iridophore cell fate, is poorly understood.

Results

We chart the global changes in the epigenetic landscape, including DNA methylation and chromatin accessibility, during neural crest differentiation into melanoph

SUBMITTER: Jang HS 

PROVIDER: S-EPMC8489059 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature