Identification, visualization, statistical analysis and mathematical modeling of high-feedback loops in gene regulatory networks.

ABSTRACT:

Background

Feedback loops in gene regulatory networks play pivotal roles in governing functional dynamics of cells. Systems approaches demonstrated characteristic dynamical features, including multistability and oscillation, of positive and negative feedback loops. Recent experiments and theories have implicated highly interconnected feedback loops (high-feedback loops) in additional nonintuitive functions, such as controlling cell differentiation rate and multistep cell lineage progression. However, it remains challenging to identify and visualize high-feedback loops in complex gene regulatory networks due to the myriad of ways in which the loops can be combined. Furthermore, it is unclear whether the high-feedback loop structures with these potential functions are widespread in b

SUBMITTER: Nordick B 

PROVIDER: S-EPMC8489061 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature