The susceptibility of the aortic root: porcine aortic rupture testing under cardiopulmonary bypass.

ABSTRACT:

Background

In our earlier study on the functional limits of the aneurysmal aortic root we determined the pig root is susceptible to failure at high aortic pressures levels. We established a pig rupture model using cardiopulmonary bypass to determine the most susceptible region of the aortic root under the highest pressures achievable using continuous flow, and what changes occur in these regions on a macroscopic and histological level. This information may help guide clinical management of aortic root and ascending aorta pathology.

Methods

Five pigs underwent 4D flow MRI imaging pre surgery to determine vasopressor induced wall sheer stress and flow parameters. All pigs were then placed on cardiopulmonary bypass (CPB) via median sternotomy, and maximal aortic root and ascend

SUBMITTER: Surman TL 

PROVIDER: S-EPMC8489069 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature