Systemic and intrathecal baclofen produce bladder antinociception in rats.

ABSTRACT:

Background

Baclofen, a clinically available GABA_B receptor agonist, produces non-opioid analgesia in multiple models of pain but has not been tested for effects on bladder nociception.

Methods

A series of experiments examined the effects of systemic and spinally administered baclofen on bladder nociception in female anesthetized rats. Models of bladder nociception included those which employed neonatal and adult bladder inflammation to produce bladder hypersensitivity.

Results

Cumulative intraperitoneal dosing (1-8 mg/kg IP) and cumulative intrathecal dosing (10-160 ng IT) of baclofen led to dose-dependent inhibition of visceromotor responses (VMRs) to urinary bladder distension (UBD) in all tested models. There were no differences in the magnitude of the a

SUBMITTER: Ness TJ 

PROVIDER: S-EPMC8489106 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature