Dose-dependent Respiratory Depression by Remifentanil in the Rabbit Parabrachial Nucleus/Kolliker-Fuse Complex and Pre-Botzinger Complex.

ABSTRACT:

Background

Recent studies showed partial reversal of opioid-induced respiratory depression in the pre-Bötzinger complex and the parabrachial nucleus/Kölliker-Fuse complex. The hypothesis for this study was that opioid antagonism in the parabrachial nucleus/Kölliker-Fuse complex plus pre-Bötzinger complex completely reverses respiratory depression from clinically relevant opioid concentrations.

Methods

Experiments were performed in 48 adult, artificially ventilated, decerebrate rabbits. The authors decreased baseline respiratory rate ~50% with intravenous, "analgesic" remifentanil infusion or produced apnea with remifentanil boluses and investigated the reversal with naloxone microinjections (1 mM, 700 nl) into the Kölliker-Fuse nucleus, parabrachial nucleus, and pre-Bötzinge

SUBMITTER: Palkovic B 

PROVIDER: S-EPMC8489159 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature