Circulating microRNA in patients with popliteal and multiple artery aneurysms.

ABSTRACT:

Background

Patients with popliteal artery aneurysm (PA) often have multiple aneurysms, such as bilateral disease or a concomitant abdominal aortic aneurysm (AAA). microRNAs (miRs) are regulators of biological processes and have been investigated as biomarkers for AAA. The aim of this study was to explore if the presence of multiple aneurysms and/or location correlated with miR levels in blood.

Methods

Using quantitative polymerase chain reaction, 23 miRs were analyzed in plasma from 183 patients with PA.

Results

Fifteen of the miRs were associated with the number and/or location of aneurysms (1.3- to 2.1-fold changes). Levels of miR-93 (1.4-fold) and miR-215 (1.6- to 1.9-fold) were changed in all compared groups. MiR-24 and miR-23a were altered in those with AAA (1.4-

SUBMITTER: Wagsater D 

PROVIDER: S-EPMC8489194 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature