Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior.

ABSTRACT: Cocaine, amphetamine, and methamphetamine abuse disorders are serious worldwide health problems. To date, there are no FDA-approved medications for the treatment of these disorders. Elucidation of the biochemical underpinnings contributing to psychostimulant addiction is critical for the development of effective therapies. Excitatory signaling and glutamate homeostasis are well known pathophysiological substrates underlying addiction-related behaviors spanning multiple types of psychostimulants. To alleviate relapse behavior to psychostimulants, considerable interest has focused on GLT-1, the major glutamate transporter in the brain. While many brain regions are implicated in addiction behavior, this review focuses on two regions well known for their role in mediating the effects of cocain

SUBMITTER: Fischer KD 

PROVIDER: S-EPMC8489281 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature