Efficacy and safety of antidepressants for the treatment of back pain and osteoarthritis: systematic review and meta-analysis.

ABSTRACT:

Objective

To investigate the efficacy and safety of antidepressants for back and osteoarthritis pain compared with placebo.

Design

Systematic review and meta-analysis.

Data sources

Medline, Embase, Cochrane Central Register of Controlled Trials, CINAHL, International Pharmaceutical Abstracts, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry Platform from inception to 15 November and updated on 12 May 2020.

Eligibility criteria for study selection

Randomised controlled trials comparing the efficacy or safety, or both of any antidepressant drug with placebo (active or inert) in participants with low back or neck pain, sciatica, or hip or knee osteoarthritis.

Data extraction and synthesis

Two independent reviewers

SUBMITTER: Ferreira GE 

PROVIDER: S-EPMC8489297 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature