Cannabidiol (CBD) Oil Does Not Display an Entourage Effect in Reducing Cancer Cell Viability in vitro.

ABSTRACT:

Introduction

Several studies have found that cannabinoids, particularly delta-9-tetrahydrocannabinol and cannabidiol (CBD), have the ability to reduce cancer cell viability. An ongoing debate regarding the use of medical Cannabis revolves around the effectiveness of pure compounds versus intact plant material for treatment. Proponents for the use of intact plant material or botanical extracts argue that there is a synergistic effect between the different cannabinoids, terpenoids, and flavonoids; this is commonly referred to as the "entourage effect." Our study was designed to test the validity of the proposed entourage effect in a narrow application using a cancer cell viability model.

Materials and methods

Six cancer cell lines, from 3 different types of human cancer were t

SUBMITTER: Raup-Konsavage WM 

PROVIDER: S-EPMC8489314 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature