Semantic Recollection in Parkinson's Disease: Functional Reconfiguration and MAPT Variants.

ABSTRACT: Decline in semantic cognition in early stages of Parkinson's disease (PD) is a leading risk factor for future dementia, yet the underlying neural mechanisms are not understood. The present study addressed this gap by investigating the functional connectivity of regions involved in semantic recollection. We further examined whether microtubule-associated protein tau (MAPT) risk variants, which may accelerate cognitive decline, altered the strength of regional functional connections. Cognitively normal PD and healthy elder controls underwent fMRI while performing a fame-discrimination task, which activates the semantic network. Analyses focused on disturbances in fame-modulated functional connectivity in PD for regions that govern semantic recollection and interrelated processes. Group diffe

SUBMITTER: Harrington DL 

PROVIDER: S-EPMC8489380 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature