Transporting Subgroup Analyses of Randomized Controlled Trials for Planning Implementation of New Interventions.

ABSTRACT: Subgroup analyses of randomized controlled trials guide resource allocation and implementation of new interventions by identifying groups of individuals who are likely to benefit most from the intervention. Unfortunately, trial populations are rarely representative of the target populations of public health or clinical interest. Unless the relevant differences between trial and target populations are accounted for, subgroup results from trials might not reflect which groups in the target population will benefit most from the intervention. Transportability provides a rigorous framework for applying results derived in potentially highly selected study populations to external target populations. The method requires that researchers measure and adjust for all variables that 1) modify the effec

SUBMITTER: Mehrotra ML 

PROVIDER: S-EPMC8489435 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature