Cardiovascular Safety of Metoclopramide Compared to Domperidone: A Population-Based Cohort Study.

ABSTRACT:

Background

Metoclopramide and domperidone are common prokinetics used to alleviate gastrointestinal symptoms. However, both drugs may trigger ventricular arrhythmias.

Aim

We conducted this population-based study to compare the 30-day cardiovascular safety of metoclopramide versus domperidone in outpatient care.

Methods

We used health care databases to identify a cohort of patients in Ontario, Canada newly dispensed metoclopramide or domperidone. Inverse probability of treatment weighting based on propensity scores was used to balance the baseline characteristics of the two groups. All outcomes were assessed in the 30 days following drug dispensing. The primary outcome was hospital encounter with ventricular arrhythmia. The secondary outcomes were hospital encounter wi

SUBMITTER: Cowan A 

PROVIDER: S-EPMC8489520 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature