Lipocalin 2 Is a Regulator During Macrophage Polarization Induced by Soluble Worm Antigens.

ABSTRACT: Caused by schistosomes, the human schistosomiasis is a tropical zoonotic parasitic disease. Pathologically, it occurs most often in the intestines and the liver, the sites of Schistosoma japonicum egg accumulation. The parasites' produced eggs cause the main pathology in patients. Deposited parasite eggs in the liver induce the production of multiple cytokines that mediate the immune response, which in turn leads to granulomatous responses and liver fibrosis. These impact the hosts' quality of life and health status, resulting in severe morbidity and even mortality. In this study, differentially expressed genes (DEGs) between ordinary samples and three 6- week infected mice were mined from microarray analysis based on the limma package. In total, we excavated the differential expres

SUBMITTER: Shen H 

PROVIDER: S-EPMC8489661 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature