Emergent spatiotemporal population dynamics with cell-length control of synthetic microbial consortia.

ABSTRACT: The increased complexity of synthetic microbial biocircuits highlights the need for distributed cell functionality due to concomitant increases in metabolic and regulatory burdens imposed on single-strain topologies. Distributed systems, however, introduce additional challenges since consortium composition and spatiotemporal dynamics of constituent strains must be robustly controlled to achieve desired circuit behaviors. Here, we address these challenges with a modeling-based investigation of emergent spatiotemporal population dynamics using cell-length control in monolayer, two-strain bacterial consortia. We demonstrate that with dynamic control of a strain's division length, nematic cell alignment in close-packed monolayers can be destabilized. We find that this destabilization confers a

SUBMITTER: Winkle JJ 

PROVIDER: S-EPMC8489724 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature