Diffusion-weighted MR imaging in chronic non-bacterial osteitis: Proof-of-concept of the apparent diffusion coefficient as an outcome measure.

ABSTRACT:

Background

The apparent diffusion coefficient (ADC), as determined by whole-body diffusion-weighted MRI, may be useful as an outcome measure for monitoring response to treatment in chronic non-bacterial osteitis.

Purpose

To test and demonstrate the feasibility of ADC-measurement methods for use as outcome measure in chronic non-bacterial osteitis.

Materials and methods

Using data from a randomized pilot study, feasibility of change-score ADC between baseline and second MRI (ΔADC₁₂) and third MRI (ΔADC₁₃) as outcome measure was assessed in three settings: "whole-lesion," "single-slice per lesion," and "index-lesion per patient". Bone marrow edema lesions were depicted on short tau inversion recovery sequence at baseline and copied to ADC maps at t

SUBMITTER: Moller JM 

PROVIDER: S-EPMC8489758 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature