Highly Reproducible Hyperthermia Response in Water, Agar, and Cellular Environment by Discretely PEGylated Magnetite Nanoparticles.

ABSTRACT: Local heat generation from magnetic nanoparticles (MNPs) exposed to alternating magnetic fields can revolutionize cancer treatment. However, the application of MNPs as anticancer agents is limited by serious drawbacks. Foremost among these are the fast uptake and biodegradation of MNPs by cells and the unpredictable magnetic behavior of the MNPs when they accumulate within or around cells and tissues. In fact, several studies have reported that the heating power of MNPs is severely reduced in the cellular environment, probably due to a combination of increased viscosity and strong NP agglomeration. Herein, we present an optimized protocol to coat magnetite (Fe₃O₄) NPs larger than 20 nm (FM-NPs) with high molecular weight PEG molecules that avoid collective coatings, p

SUBMITTER: Castellanos-Rubio I 

PROVIDER: S-EPMC8489799 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature