Short chain fatty acids inhibit endotoxin-induced uveitis and inflammatory responses of retinal astrocytes.

ABSTRACT: Short chain fatty acids (SCFAs) are produced by gut microbiota as fermentation products of digestion-resistant oligosaccharides and fibers. Their primary roles are functioning as major energy sources for colon cells and assisting in gut homeostasis by immunomodulation. Recent evidence suggests that they affect various organs both at cellular and molecular levels, and regulate functions in distance sites including gene expression, cell proliferation, cell differentiation, apoptosis and inflammation. In this study, we examined whether SCFAs are present in the mouse eye and whether SCFAs affect inflammatory responses of the eye and retinal astrocytes (RACs). We observed that intra-peritoneal injected SCFAs were detected in the eye and reduced intraocular inflammation induced by lipopolysaccha

SUBMITTER: Chen N 

PROVIDER: S-EPMC8489808 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature