Long-term Follow-up of Preoperative Infant Event-related Potentials in School-age Children with Craniosynostosis.

ABSTRACT:

Background

Previous studies demonstrated impaired auditory processing in children with sagittal and metopic craniosynostosis before surgical correction. This study investigated whether worse presurgical neural response as assessed by event-related potentials (ERP) was predictive of poorer school-age neurocognition.

Methods

Preoperative infant ERP was recorded in 15 sagittal and 18 metopic patients. Mismatch negativity and P150 paradigms were derived from ERP recordings, as previously published. Of those, 13 sagittal and 13 metopic patients returned for neurocognitive evaluation 6 or more years later. ERP was correlated to neurocognitive outcomes using Spearman's correlations controlling for age. Two-tailed t-tests were used to evaluate the influence of age at the time of sur

SUBMITTER: Junn A 

PROVIDER: S-EPMC8489894 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature