Mucins, gut microbiota, and postbiotics role in colorectal cancer.

ABSTRACT: An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host and gut microbiota via different dietary patterns (prebiotics

SUBMITTER: Pothuraju R 

PROVIDER: S-EPMC8489937 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature