Mechanisms Underlying the Association of Chronic Obstructive Pulmonary Disease With Heart Failure.

ABSTRACT:

Objectives

The purposes of this study were to determine why chronic obstructive pulmonary disease (COPD) is associated with heart failure (HF). Specific objectives included whether COPD is associated with myocardial fibrosis, whether myocardial fibrosis is associated with hospitalization for HF and death in COPD, and whether COPD and smoking are associated with myocardial inflammation.

Background

COPD is associated with HF independent of shared risk factors. The underlying pathophysiological mechanism is unknown.

Methods

A prospective, multicenter, longitudinal cohort study of 572 patients undergoing cardiac magnetic resonance (CMR), including 450 patients with COPD and 122 age- and sex-matched patients with a median: 726 days (interquartile range: 492 to 1,160 days)

SUBMITTER: Lagan J 

PROVIDER: S-EPMC8490158 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature