Urinary metals and metal mixtures and timing of natural menopause in midlife women: The Study of Women's Health Across the Nation.

ABSTRACT:

Background

Exposure to metals and metal mixtures may influence ovarian aging. However, epidemiologic evidence of their potential impact is lacking.

Objective

We prospectively examined the associations of 15 urinary metal concentrations and their mixtures with natural menopause in the Study of Women's Health Across the Nation Multi-Pollutant Study.

Methods

The study population consisted of 1082 premenopausal women from multiple racial/ethnic groups, aged 45-56 years at baseline (1999-2000), with the median follow-up of 4.1 years. Urinary concentrations of 15 metals, including arsenic, barium, cadmium, cobalt, cesium, copper, mercury, manganese, molybdenum, nickel, lead, antimony, tin, thallium, and zinc, were measured at baseline. Natural menopause was defined as the f

SUBMITTER: Wang X 

PROVIDER: S-EPMC8490279 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature