Neurological Complications Acquired During Pediatric Critical Illness: Exploratory "Mixed Graphical Modeling" Analysis Using Serum Biomarker Levels.

ABSTRACT:

Objectives

Neurologic complications, consisting of the acute development of a neurologic disorder, that is, not present at admission but develops during the course of illness, can be difficult to detect in the PICU due to sedation, neuromuscular blockade, and young age. We evaluated the direct relationships of serum biomarkers and clinical variables to the development of neurologic complications. Analysis was performed using mixed graphical models, a machine learning approach that allows inference of cause-effect associations from continuous and discrete data.

Design

Secondary analysis of a previous prospective observational study.

Setting

PICU, single quaternary-care center.

Patients

Individuals admitted to the PICU, younger than18 years old, with intravascula

SUBMITTER: Raghu VK 

PROVIDER: S-EPMC8490289 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature