Pharmacological and simulated exercise cardiac stress tests produce different ischemic signatures in high-resolution experimental mapping studies.

ABSTRACT:

Objective

Test the hypothesis that exercise and pharmacological cardiac stressors create different electrical ischemic signatures.

Introduction

Current clinical stress tests for detecting ischemia lack sensitivity and specificity. One unexplored source of the poor detection is whether pharmacological stimulation and regulated exercise produce identical cardiac stress.

Methods

We used a porcine model of acute myocardial ischemia in which animals were instrumented with transmural plunge-needle electrodes, an epicardial sock array, and torso arrays to simultaneously measure cardiac electrical signals within the heart wall, the epicardial surface, and the torso surface, respectively. Ischemic stress via simulated exercise and pharmacological stimulation were created with

SUBMITTER: Zenger B 

PROVIDER: S-EPMC8490320 | biostudies-literature | 2021 Sep-Oct

REPOSITORIES: biostudies-literature