Longitudinal exposure to consumer product chemicals and changes in plasma oxylipins in pregnant women.

ABSTRACT:

Background

Exposure to consumer product chemicals during pregnancy may increase susceptibility to pregnancy disorders by influencing maternal inflammation. However, effects on specific inflammatory pathways have not been well characterized. Oxylipins are a diverse class of lipids that act as important mediators and biomarkers of several biological pathways that regulate inflammation. Adverse pregnancy outcomes have been associated with circulating oxylipin levels in pregnancy. In this study, we aimed to determine the longitudinal associations between plasma oxylipins and urinary biomarkers of three classes of consumer product chemicals among pregnant women.

Methods

Data come from a study of 90 pregnant women nested within the LIFECODES cohort. Maternal plasma and urine were

SUBMITTER: Welch BM 

PROVIDER: S-EPMC8490329 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature