A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis.

ABSTRACT: NF-kappaB (NF-κB) is a family of transcription factors with pleiotropic functions in immune responses. The alternative NF-κB pathway that leads to the activation of RelB and NF-κB2, was previously associated with the activation and function of T cells, though the exact contribution of these NF-κB subunits remains unclear. Here, using mice carrying conditional ablation of RelB in T cells, we evaluated its role in the development of conventional CD4⁺ T (Tconv) cells and their function in autoimmune diseases. RelB was largely dispensable for Tconv cell homeostasis, activation and proliferation, and for their polarization toward different flavors of Thelper cells in vitro. Moreover, ablation of RelB had no impact on the capacity of Tconv cells to induce autoimmune colitis. Conversel

SUBMITTER: Lalle G 

PROVIDER: S-EPMC8490410 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature