Divergent connectomic organization delineates genetic evolutionary traits in the human brain.

ABSTRACT: The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insights are provided about the relationship between connectomics, gene expression and divergent evolutionary pathways from non-human primates to humans. Using in vivo human brain resting-state data, we detected two co-existing idiosyncratic functional systems: the segregation network, in charge of module specialization, and the integration network, responsible for information flow. Their topology was approximated to whole-brain genetic expression (Allen Human Brain Atlas) and the co-localization patterns yielded that neuron communication functionalities-linked to Neuron Projection-were over

SUBMITTER: Bueicheku E 

PROVIDER: S-EPMC8490416 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature