Inhibiting endocytosis in CGRP⁺ nociceptors attenuates inflammatory pain-like behavior.

ABSTRACT: The advantage of locally applied anesthetics is that they are not associated with the many adverse effects, including addiction liability, of systemically administered analgesics. This therapeutic approach has two inherent pitfalls: specificity and a short duration of action. Here, we identified nociceptor endocytosis as a promising target for local, specific, and long-lasting treatment of inflammatory pain. We observed preferential expression of AP2α2, an α-subunit isoform of the AP2 complex, within CGRP⁺/IB4^- nociceptors in rodents and in CGRP⁺ dorsal root ganglion neurons from a human donor. We utilized genetic and pharmacological approaches to inhibit nociceptor endocytosis demonstrating its role in the development and maintenance of acute and chronic i

SUBMITTER: Powell R 

PROVIDER: S-EPMC8490418 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature