Panel-reactive Antibody and the Association of Early Steroid Withdrawal With Kidney Transplant Outcomes.

ABSTRACT:

Background

Early steroid withdrawal (ESW) is a viable maintenance immunosuppression strategy in low-risk kidney transplant recipients. A low panel-reactive antibody (PRA) may indicate low-risk condition amenable to ESW. We aimed to identify the threshold value of PRA above which ESW may pose additional risk and to compare the association of ESW with transplant outcomes across PRA strata.

Methods

We studied 121 699 deceased-donor kidney-only recipients in 2002-2017 from Scientific Registry of Transplant Recipients. Using natural splines and ESW-PRA interaction terms, we explored how the associations of ESW with transplant outcomes change with increasing PRA values and identified a threshold value for PRA. Then, we assessed whether PRA exceeding the threshold modified the asso

SUBMITTER: Bae S 

PROVIDER: S-EPMC8490476 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature