BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators.

ABSTRACT: Cell cycle regulators are frequently altered in Triple-Negative Breast Cancer (TNBC). Emerging agents targeting these signals offer the possibility to design new combinatorial therapies. However, preclinical models that recapitulate TNBC primary resistance and heterogeneity are essential to evaluate the potency of these combined treatments. Methods: Bioinformatic processing of human breast cancer datasets was used to analyse correlations between expression levels of cell cycle regulators and patient survival outcome. The MMTV-R26^Met mouse model of TNBC resistance and heterogeneity was employed to analyse expression and targeting vulnerability of cell cycle regulators in the presence of BCL-XL blockage. Robustness of outcomes and selectivity was further explored usi

SUBMITTER: Castellanet O 

PROVIDER: S-EPMC8490507 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature