Proteomic analysis of lung cancer cells reveals a critical role of BCAT1 in cancer cell metastasis.

ABSTRACT: Metastasis is the major cause of high mortality in lung cancer. Exploring the underlying mechanisms of metastasis thus holds promise for identifying new therapeutic strategies that may enhance survival. Methods: We applied quantitative mass spectrometry to compare protein expression profiles between primary and metastatic lung cancer cells whilst investigating metastasis-related molecular features. Results: We discovered that BCAT1, the key enzyme in branched-chain amino acid metabolism, is overexpressed at the protein level in metastatic lung cancer cells, as well as in metastatic tissues from lung cancer patients. Analysis of transcriptomic data available in the TCGA database revealed that increased BCAT1 transcription is associated with poor overall survival of lung cancer

SUBMITTER: Mao L 

PROVIDER: S-EPMC8490523 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature