Benefits of functional assays in personalized cancer medicine: more than just a proof-of-concept.

ABSTRACT: As complex and heterogeneous diseases, cancers require a more tailored therapeutic management than most pathologies. Recent advances in anticancer drug development, including the immuno-oncology revolution, have been too often plagued by unsatisfying patient response rates and survivals. In reaction to this, cancer care has fully transitioned to the "personalized medicine" concept. Numerous tools are now available tools to better adapt treatments to the profile of each patient. They encompass a large array of diagnostic assays, based on biomarkers relevant to targetable molecular pathways. As a subfamily of such so-called companion diagnostics, chemosensitivity and resistance assays represent an attractive, yet insufficiently understood, approach to individualize treatments. They rely on t

SUBMITTER: Morand du Puch CB 

PROVIDER: S-EPMC8490527 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature