Effect of polymorphisms of MTHFR in controlled ovarian stimulation: a systematic review and meta-analysis.

ABSTRACT:

Objective

Although several studies have reported a potential impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on controlled ovarian stimulation (COS), the results remain controversial. The aim of the systematic review and meta-analysis was to evaluate the effect of MTHFR polymorphism on COS outcomes.

Methods

PubMed, Web of Science, Embase, and Cochrane Central Register of Controlled Trials databases were searched up to December 2, 2020. COS clinical outcomes based on gene polymorphisms were included. Two reviewers independently extracted the data. The primary outcome was the number of oocytes retrieved. The secondary outcomes were the number of metaphase II (MII) oocytes, stimulation duration, basal follicle-stimulating hormone (FSH) level, FSH dosage, pos

SUBMITTER: Wang X 

PROVIDER: S-EPMC8490531 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature