A Systematic Review of Intravenous β-Hydroxybutyrate Use in Humans - A Promising Future Therapy?

ABSTRACT: Therapeutic ketosis is traditionally induced with dietary modification. However, owing to the time delay involved, this is not a practical approach for treatment of acute conditions such as traumatic brain injury. Intravenous administration of ketones would obviate this problem by rapidly inducing ketosis. This has been confirmed in a number of small animal and human studies. Currently no such commercially available product exists. The aim of this systematic review is to review the safety and efficacy of intravenous beta-hydroxybutyrate. The Web of Science, PubMed and EMBASE databases were searched, and a systematic review undertaken. Thirty-five studies were included. The total beta-hydroxybutyrate dose ranged from 30 to 101 g administered over multiple doses as a short infusion, with mos

SUBMITTER: White H 

PROVIDER: S-EPMC8490680 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature