Ontology highlight
ABSTRACT:
SUBMITTER: Dong T
PROVIDER: S-EPMC8490775 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Dong Tingting T Zhang Xuejie X Liu Yiqing Y Xu Shan S Chang Haishuang H Chen Fengqiu F Pan Lulu L Hu Shaoru S Wang Min M Lu Min M
Frontiers in cell and developmental biology 20210921
Optic atrophy1 (OPA1) is crucial for inner mitochondrial membrane (IMM) fusion and essential for maintaining crista structure and mitochondrial morphology. Optic atrophy and hearing impairment are the most prevalent clinical features associated with mutations in the <i>OPA1</i> gene, but the function of OPA1 in hearing is still unknown. In this study, we examined the ability of Opa1 to protect against cisplatin-induced cochlear cell death <i>in vitro</i> and <i>in vivo</i>. Our results revealed ...[more]