Non-invasive capnodynamic mixed venous oxygen saturation during major changes in oxygen delivery.

ABSTRACT: Mixed venous oxygen saturation (SvO₂) is an important variable in anesthesia and intensive care but currently requires pulmonary artery catheterization. Recently, non-invasive determination of SvO₂ (Capno-SvO₂) using capnodynamics has shown good agreement against CO-oximetry in an animal model of modest hemodynamic changes. The purpose of the current study was to validate Capno-SvO₂ against CO-oximetry during major alterations in oxygen delivery. Furthermore, evaluating fiberoptic SvO₂ for its response to the same challenges. Eleven mechanically ventilated pigs were exposed to oxygen delivery changes: increased inhaled oxygen concentration, hemorrhage, crystalloid and blood transfusion, preload reduction and dobutamine infusion. Capno-

SUBMITTER: Svedmyr A 

PROVIDER: S-EPMC8490846 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature